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Research AreasMicroarray Spike-in Data: Rafael Irizarry and I have developed a comprehensive statistical analysis strategy for data from microarray spike-in experiments. We demonstrated the utility of our method by making the first comparison of the three major microarray manufacturers (Affymetrix, Agilent, and Illumina).Frozen Robust Multi-Array Analysis (fRMA): An adaptation of RMA to handle single microarray hybridizations as well as huge datasets. Microarray Expression Barcode: I am currently working on improving the expression barcode originally proposed by Rafael Irizarry and Michael Zilliox. The goal of this research is to be able to accurately determine which genes are expressed and which genes are unexpressed in a tissue based on a single microarray hybridization. |
PublicationsMcCall, MN and Irizarry RA (2008). Consolidated strategy for the analysis of microarray spike-in data, Nucleic Acids Research, 36(17), e108.Sachin, S, McCall, MN, Eveleigh, D, Wilson, M, and Irizarry, RA (2010). Performance evaluation of commercial miRNA expression array platforms, BMC Research Notes, 3:80, doi:10.1186/1756-0500-3-80 McCall, MN, Bolstad, BM, and Irizarry, RA (2010). Frozen robust multiarray analysis (fRMA), Biostatistics 2010, doi: 10.1093/biostatistics/kxp059 McCall, MN, Zilliox, MJ, and Irizarry, RA (2009). Gene Expression Barcodes Based on Data from 8,277 Microarrays, Working Paper. |
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