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Sameer Paithankar

M.H.S Bioinformatics Capstone Project

Abstract

This project compares the two single nucleotide polymorphisms (SNPs) calling programs: CRLMM (Dept of Biostatistics, Johns Hopkins University) and Birdseed (Broad) . I have done several types of analysis to compare these two algorithms. I find that CRLMM outperforms Birdseed on a variety of Affymetrix platforms. I have also shown how the quality of arrays can affect genotyping accuarcy